Direct molecule-specific glucose detection by Raman spectroscopy based on photonic crystal fiber |
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Authors: | Xuan?Yang Alissa?Y?Zhang Damon?A?Wheeler Tiziana?C?Bond Email author" target="_blank">Claire?GuEmail author Email author" target="_blank">Yat?LiEmail author |
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Institution: | (1) Department of Electrical Engineering, University of California, Santa Cruz, Santa Cruz, CA 95064, USA;(2) Department of Chemistry and Biochemistry, University of California, Santa Cruz, Santa Cruz, CA 95064, USA;(3) Lawrence Livermore National Laboratory, Livermore, CA 94550, USA; |
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Abstract: | This paper reports the first step toward the development of a glucose biosensor based on Raman spectroscopy and a photonic
crystal fiber (PCF) probe. Historically, it has been very challenging to detect glucose directly by Raman spectroscopy due
to its inherently small Raman scattering cross-section. In this work, we report the first quantitative glucose Raman detection
in the physiological concentration range (0–25 mM) with a low laser power (2 mW), a short integration time (30 s), and an
extremely small sampling volume (∼50 nL) using the highly sensitive liquid-filled PCF probe. As a proof of concept, we also
demonstrate the molecular specificity of this technique in the presence of a competing sugar, such as fructose. High sensitivity,
flexibility, reproducibility, low cost, small sampling volume, and in situ remote sensing capability make PCF a very powerful
platform for potential glucose detection based on Raman spectroscopy. |
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