Analysis of phase transition and dehydration processes of nevirapine |
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| Authors: | George G. G. de Oliveira Humberto G. Ferraz Patrícia Severino Eliana B. Souto |
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| Affiliation: | 1.Department of Pharmacy, Faculty of Pharmaceutical Sciences,University of S?o Paulo,S?o Paulo,Brazil;2.Department of Biotechnological Processes, School of Engineering Chemical,University of Campinas,Campinas,Brazil;3.Department of Pharmaceutical Technology, Faculty of Health Sciences,Fernando Pessoa University,Porto,Portugal;4.Institute for Biotechnology and Bioengineering, Centre of Genomics and Biotechnology,University of Trás-os-Montes e Alto Douro (IBB-CGB/UTAD),Vila Real,Portugal |
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| Abstract: | Solid-state characterization of crystalline drugs is an important pre-formulation step for the development and design of solid dosage forms, such as pellets and tablets. In this study, phase transition and dehydration processes of nevirapine have been studied by differential scanning calorimetry and thermogravimetry differential thermal analysis to overcome the problems of drug formulation, namely poor solubility and poor content uniformity. Phase solubility studies elucidated the mechanism of enhanced nevirapine solubility. |
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