| Synthesis of 4(3H)-Quinazolinone Derivatives and Their in vitro Antitumor Activity |
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| 引用本文： | CAO,Sheng-Li FENG,Yu-Ping FU,Hua FENG,Ke-Ran. Synthesis of 4(3H)-Quinazolinone Derivatives and Their in vitro Antitumor Activity[J]. 有机化学, 2004, 24(Z1): 247-248 |
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| 作者姓名： | CAO Sheng-Li FENG Yu-Ping FU Hua FENG Ke-Ran |
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| 作者单位： | CAO,Sheng-Li（Department of Chemistry, Capital Normal University, Beijing 100037） FENG,Yu-Ping（Key Laboratory of Bioorganic Phosphorus Chemistry, Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084） FU,Hua（Key Laboratory of Bioorganic Phosphorus Chemistry, Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084） FENG,Ke-Ran（Department of Chemistry, Capital Normal University, Beijing 100037） |
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| 基金项目： | 北京市自然科学基金，the Natural Science Foundation of Beijing City |
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| 摘 要： | Classical antifolates containing L-glutamic acid moiety in molecule have shortcomings such as drug resistance which is originated from the defective cell transport by mutation, and toxicity to the host which is due to unnecessarily long retention inside normal cells.[1] One strategy to overcome these shortcomings is to design nonclassical lipophilic inhibitors of folate requiring enzymes by deleting or modifying L-glutamic acid component from the folate analogues.
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Synthesis of 4(3H)-Quinazolinone Derivatives and Their in vitro Antitumor Activity |
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| CAO,Sheng-Li,FENG,Yu-Ping,FU,Hua,FENG,Ke-Ran. Synthesis of 4(3H)-Quinazolinone Derivatives and Their in vitro Antitumor Activity[J]. Chinese Journal of Organic Chemistry, 2004, 24(Z1): 247-248 |
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| Authors: | CAO Sheng-Li FENG Yu-Ping FU Hua FENG Ke-Ran |
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| Abstract: | Classical antifolates containing L-glutamic acid moiety in molecule have shortcomings such as drug resistance which is originated from the defective cell transport by mutation, and toxicity to the host which is due to unnecessarily long retention inside normal cells.[1] One strategy to overcome these shortcomings is to design nonclassical lipophilic inhibitors of folate requiring enzymes by deleting or modifying L-glutamic acid component from the folate analogues. |
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