Synthesis of 5-substituted pyrimidines. ortho-directed lithiation of pyrimidine derivatives |
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Authors: | Akimori Wada,Junpei Yamamoto,Yuka Hamaoka,Kazuhiro Ohki,Sotoo Nagai,Sh
ichi Kanatomo |
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Affiliation: | Akimori Wada,Junpei Yamamoto,Yuka Hamaoka,Kazuhiro Ohki,Sotoo Nagai,Shōichi Kanatomo |
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Abstract: | ortho-Directed lithiation of some pyrimidines has been investigated. Treatment of 2- and/or 4-alkoxy or acylaminopyrimidine with lithium 2,2,6,6-tetramethylpiperidide in ether at 0°, followed by quenching with various electrophiles afforded the corresponding 5-substituted pyrimidines. |
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