Synthesis and In vitro biological activity of some 7-(5-aminomethyl-2-isoxazolidinyl)quinolone-3-carboxylic acids

The synthesis of the title compounds via nitrone cycloaddition is described. The in vitro antibacterial activity of these compounds is compared against 1-ethyl-6,8-difluoro-7-3-(ethylamino)methyl]-1-pyrrolidinyl]-1,4-dihydro-4-oxoquinoline-3-carboxylic acid (CI-934).