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5-Methylnaioxone and 5-Methylnaltrexone: Synthesis and Pharmacological Evaluation |
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| Authors: | Helmut Schmidhammer Karin Mayer-Valkanover Michaela Walla-Kugler |
| Abstract: | Starting from 5-methyl-oxycodone ( 6 ), 5-methylnaloxone ( 4 ), and 5-methylnaltrexone ( 5 ) have been prepared in several steps. Both 4 and 5 behaved as partial agonists in the AcOH writhing agonism and antagonism test in mice. |
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