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New synthetic method for 4-hydroxyproline |
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| Authors: | Giovanni De Martino Paolo De Caprariis Enrico Abignente Maria Grazia Rimoli |
| Abstract: | A new synthesis of 4-hydroxyproline was carried out starting from diethyl p-nitrobenzoylaminomalonate, which was converted by a three steps pathway into diethyl 4-hydroxy-1-(4-nitrobenzoyl)pyrrolidine-2,2-dicarboxylate, which afforded 4-hydroxyproline via acid hydrolysis. |
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