8-Bromo-6-alkylamino-2-trifluoromethyl-9H-purines with in vitro activity against influenza a virus

Several derivatives of 8-bromo-6-dimethylamino-2-trifluoromethyl-9H-purine ( 1 ) were synthesized for structure-activity relationship studies of anti-influenza A virus activity. The 8-bromopurines were prepared by reaction of the anion of the 6-alkylamino-2-trifluoromethylpurines with N-bromosuccinimide. Several compounds had anti-influenza activity comparable to ribavirin, but no in vivo activity was observed.