Phenylurethans of pyrazolidinols and piperidazinols as anticonvulsants

The synthesis of 1,2-diethyl-4-hydroxymethylpyrazolidine ( II ) was accomplished in two steps from 1,2-diethyl-4-ethoxycarbonylpyrazolidine ( I ). Also, 1,2-dimethyl-4-hydroxypiperidazine ( VI ) was prepared in three steps from 1,2-diethoxycarbonyl-1,2,3,6-tetrahydropyridazine ( IV ). The two alcohols were added to several aryl isocyanates and afforded fourteen new phenylurethan derivatives which showed moderate anticonvulsant activity in mice.