Synthesis,anticancer and antimicrobiological activities of pyrrolo[2,3-d]pyrimidines |
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| Authors: | M. Luisa Quijano,Manuel Nogueras,Aldolfo S nchez,Gerardo Alvarez De Cienfuegos,Miguel Melgarejo |
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| Affiliation: | M. Luisa Quijano,Manuel Nogueras,Aldolfo Sánchez,Gerardo Alvarez De Cienfuegos,Miguel Melgarejo |
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| Abstract: | Reactions of 6-amino-3,4-dihydro-2-methoxy-4-oxopyrimidine 1a and its 3-methyl derivative 1b with chloroacetaldehyde and chloroacetyl chloride are discussed in this paper. Amongst others compounds, we have obtained, in low yield, the novel ring system oxazolo[3,2-c]pyrrolo[3,2-e]pyrimidine. The anticancer and antimicrobial activities of some of the obtained products are described. |
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