A convenient synthesis of 3-aryl-1,2,4-triazolo[4,3-c]quinazolines |
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Authors: | Mohamed M. El-Kerdawy Abd El-Kader M. Ismaiel Magdy M. Gineinah Richard A. Glennon |
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Abstract: | The synthesis and characterization of several 3-aryl-1,2,4-triazolo[4,3-c]quinazolines is described. The first step comprises the condensation of aromatic aldehydes with 2-(H or Cl)-4-hydrazinoquinazolines 2 to afford the corresponding hydrazones 3 . The second step involves the cyclization to the title compounds 4 in bromine/acetic acid. Reaction of 4 (X = Cl) with cyclic amines gave the corresponding 5-cyclicamino 5 or 5-alkoxy derivatives 6 . |
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