Synthesis,stereochemistry and conformational properties of diastereomeric cyclic dipeptides containing tetrahydro-1,4-thiazine-3,5-dicarboxylic acid |
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Authors: | Mario Paglialunga Paradisi Giampiero Pagani Zecchini Ines Torrini Gino Lucente |
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Abstract: | The synthesis of linear dipeptides containing N-protected L-phenylalanine and (3R-cis)-tetrahydro-1,4-thiazine-3,5-dicarboxylic acid dialkyl diester residues is described. N-Deprotection of these dipeptides by hydrogenolysis on palladium afforded directly a mixture of cis and trans dioxopiperazines. The stereochemistry and the solution conformational properties of the cyclic dipeptides are determined. |
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