Genomic and neural analysis of the estradiol-synthetic pathway in the zebra finch |
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Authors: | Sarah E London and David F Clayton |
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Institution: | (1) Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL, USA;(2) Beckman Institute of Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, USA;(3) Department of Cell and Developmental Biology, University of Illinois at Urbana-Champaign, Urbana, IL, USA |
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Abstract: | Background Steroids are small molecule hormones derived from cholesterol. Steroids affect many tissues, including the brain. In the zebra
finch, estrogenic steroids are particularly interesting because they masculinize the neural circuit that controls singing
and their synthesis in the brain is modulated by experience. Here, we analyzed the zebra finch genome assembly to assess the
content, conservation, and organization of genes that code for components of the estrogen-synthetic pathway and steroid nuclear
receptors. Based on these analyses, we also investigated neural expression of a cholesterol transport protein gene in the
context of song neurobiology. |
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Keywords: | |
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