An expedient enantioselective strategy for the oxatetracyclic core of platensimycin |
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| Authors: | Kaliappan Krishna P Ravikumar Velayutham |
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| Affiliation: | Department of Chemistry, Indian Institute of Technology-Bombay, Powai, Mumbai, India. kpk@chem.iitb.ac.in |
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| Abstract: | An enantioselective route for the synthesis of oxatetracyclic core of platensimycin is reported for the first time using a 5-exo-trig cyclization followed by intramolecular etherification as key reactions. The requisite dienynone for the radical cyclization is synthesized in eight steps from the Wieland-Miescher ketone employing a Claisen rearrangement. |
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