| O-乙基O-取代芳基N-异丙基硫代磷酰胺酯类化合物急性毒性与结构的相关性 |
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| 引用本文： | 焦健,毛志翔,陈启琪,徐宗藩. O-乙基O-取代芳基N-异丙基硫代磷酰胺酯类化合物急性毒性与结构的相关性[J]. 高等学校化学学报, 1987, 8(2): 128 |
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| 作者姓名： | 焦健 毛志翔 陈启琪 徐宗藩 |
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| 作者单位： | 浙江医科大学药学系 |
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| 摘 要： | 通过测定O-乙基O-取代芳基N-异丙基硫代磷酰胺酯类化合物的急性毒性、疏水性、电性、水解性,对这类化合物的急性毒性与化学结构进行了定量构-效相关(QSAR)分析。表明该类药物的急性毒性与电偶极矩μ显著相关,提示药物分子与受体的作用可能含有偶极成分。根据实验所得的QSAR方程,证明该类药物分子当电偶极矩小(苯环对位有推电子基团)、亲水性高时,其急性毒性较低。
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| 收稿时间： | 1985-08-16 |
Toxicity-Structure Relationship of O-Ethyl O-Aryl N-Isopropyl Thionophosphoramidates |
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| Jiao Jian,Mao Zhixiang,Chen Qiqi,Xu Zongfan. Toxicity-Structure Relationship of O-Ethyl O-Aryl N-Isopropyl Thionophosphoramidates[J]. Chemical Research In Chinese Universities, 1987, 8(2): 128 |
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| Authors: | Jiao Jian Mao Zhixiang Chen Qiqi Xu Zongfan |
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| Affiliation: | Department of Phxrmacy, Zhejiang Medical University Hangzhou |
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| Abstract: | Quantitative toxicity-structure relationship of O-ethyl O-aryl N-isopropyl thionophosphor-amidates was studied by the determination of their hydrophobia, electronic and hydrolytic parameters as well as their acute toxicilies towards rats. From our experimental results it seems possible that the action between organo-phosphorous toxin and receptors may include dipole interaction. According to the QSAR of our experiment, the compound with low acute toxicity may be obtained when the molecular dipole moment is small and hydrophilicity is high. |
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