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Synthesis and properties of novel aliphatic poly(carbonate-ester)s |
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| Authors: | Yu Zhou Ren-Xi Zhuo |
| Affiliation: | a Key Laboratory of Coal Conversion and New Carbon Material of Hubei Province, College of Chemical Engineering and Technology, Wuhan University of Science and Technology, Wuhan 430081, People’s Republic of China b College of Continuing Education, Wuhan University of Science and Technology, Wuhan 430081, People’s Republic of China c Key Laboratory of Biomedical Polymers of the Ministry of Education, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, People’s Republic of China |
| Abstract: | The biodegradable poly(5-methyl-5-methoxycarbonyl-1,3-dioxan-2-one-co-d,l-lactide) [poly(MMTC-co-d,l-LA)] copolymers were synthesized by the ring-opening copolymerization. The results show that the yield and molecular weight of copolymers are significantly influenced by reaction conditions. The chemical structure of the resultant copolymers was characterized by FTIR, 1H NMR and 13C NMR methods. Their molecular weight was measured by gel permeation chromatography (GPC). Study of monomer coreactivity ratios indicates that d,l-LA reacts faster than MMTC in the copolymerization. The enzymatic degradation of the polymers with various compositions was studied at 37 °C in pH = 8.6 Tris-HCl buffer solution in the presence of proteinase K. Their mechanical properties were also preliminarily investigated. |
| Keywords: | Biodegradable Polycarbonates Polyesters Proteinase K Ring-opening polymerization |
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