Preparation,characterization and biodistribution of salicylidene- and pyridoxylidene-thyroxine complexes of technetium-99m |
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| Authors: | M S Iqbal M H Rizvi A Naqvi |
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| Institution: | (1) Pakistan Atomic Energy Commission (DNFM), P.O. Box 1114, Islamabad, (Pakistan);(2) Nuclear Chemistry Division, Pakistan Institute of Nuclear Science and Technology, P.O. Nilore, Islamabad, (Pakistan) |
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| Abstract: | New Schiff bases, salicylidene- and pyridoxylidene-thyroxine have been prepared and characterized. They were labeled with99mTc. The labeling yield of the Schiff bases was over 95%. About 60% of the activity was bound to  -globulin and albumin fractions when the labled compounds were incubated with a serum sample. The labeled compounds, after i.v. administration to rats, rapidly cleared from blood and excreted into the small intestine. They appeared to behave as hepatobiliary agents. |
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