Novel syntheses of 2,3-dihydro-1,5-benzothiazepin-4(5h)-ones and 2h-1,4-benzothiazin-3(4h)-ones |
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| Authors: | Katritzky A R Odens H H Zhang S Rostek C J Maender O W |
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| Affiliation: | Flexsys America L. P., 260 Springside Drive, Akron, Ohio 44333, USA. katritzky@chem.ufl.edu |
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| Abstract: | Nucleophilic additions of alpha-mercaptoalkanoate esters and beta-mercaptoalkanoate acids to benzoquinone diimines, followed by cyclization with trifluoroacetic acid or 1,3-dicyclohexylcarbodiimide (DCC), provide novel, high-yielding syntheses of 2H-1,4-benzothiazin-3(4H)-ones (3a-f) and 2,3-dihydro-1,5-benzothiazepin-4(5H)-ones (5a-c), respectively. |
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