Synthesis of amino thiols and isocysteines via regioselective ring opening of sulfamidates with tetrathiomolybdate |
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Authors: | R.B. Nasir BaigN.Y. Phani Kumar Jamsad MannuthodikayilSrinivasan Chandrasekaran |
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Affiliation: | a Department of Organic Chemistry, Indian Institute of Science, Bangalore 560012, Karnataka, India b Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore, India |
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Abstract: | Herein we present a simple and highly efficient method for the synthesis of β and γ-amino thiols via regioselective ring opening of sulfamidates with tetrathiomolybdate 1. The generality of this methodology has been shown by synthesizing carbohydrate derived β-amino thiol. The scope and versatility of this methodology has been demonstrated by synthesizing biologically important unnatural amino acids like isocysteines in optically pure form. |
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Keywords: | Tetrathiomolybdate Sulfamidates Burgess reagent Amino thiols |
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