Synthesis of spongidines A and D: marine metabolites phospholipase A2 inhibitors |
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| Authors: | P. Basabe,A. BlancoI.S. Marcos,D. Dí ezO. Bodero,M. Martí nJ.G. Urones |
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| Affiliation: | Departamento de Química Orgánica, Facultad de Ciencias Químicas, Universidad de Salamanca, Plaza de los Caídos 1-5, 37008 Salamanca, Spain |
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| Abstract: | Two different strategies for the synthesis of spongidines A and D are presented. Herein we describe a route based in an amino acid insertion followed by aromatization. Another alternative is the construction of a pyridine derivative followed by N-alkylation. Both methodologies have intermediate 5 as a key compound, which is eventually accessible from methyl isoanticopalate. |
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| Keywords: | Sclareol Spongidines Pyridines Marine metabolites Phospholipase A2 |
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