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Palladium catalyzed stereoselective synthesis of 3-(anilinoarylmethylene)-2-oxindoles as Hesperadin analogoues |
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| Authors: | Morteza BararjanianSaeedeh Hosseinzadeh Saeed Balalaie Hamid Reza Bijanzadeh |
| Affiliation: | a Peptide Chemistry Research Center, K.N. Toosi University of Technology, P.O. Box 15875-4416 Tehran, Iran b Department of Chemistry, Tarbiat Modares University, P.O. Box 141115-175 Tehran, Iran |
| Abstract: | Potentially bioactive 3-(anilinoarylmethylene)-2-oxindoles as Hesperadin analogoues have been synthesized via a two-step procedure: (a) an Ugi-4MCR and (b) reaction of the Ugi adduct with aniline in the presence of a palladium catalyst via domino Heck/Buchwald reaction. In all cases, a single isomer with the Z-configuration was obtained in good to high yields. |
| Keywords: | Stereoselective synthesis 3-(Aminomethylene)-2-oxindoles Hesperadin Ugi-4MCR Domino Heck/Buchwald reaction |
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