Unique chemoselective Clauson-Kass reaction of substituted aniline catalyzed by MgI2 etherate |
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Authors: | Xingxian Zhang Junchen Shi |
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Affiliation: | College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, Zhejiang 310032, PR China |
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Abstract: | Clauson-Kass reaction of various substituted aniline, primary aryl amide, and sufonyl amide with 2,5-dimethoxytetrahydrofuran was realized in the presence of 10 mol % of MgI2 etherate in a mild, efficient, and highly chemoselective manner. Iodide counterion and solvents (i.e., MeCN) played the critical roles for the unique reactivity of this catalytic system. |
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Keywords: | Chemoselective Dimethoxytetrahydrofuran Pyrrole Clauson-Kaas reaction MgI2 etherate |
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