An eco-friendly procedure for one-pot synthesis of β-phosphonomalonates: micellar solution of sodium stearate catalyzes tandem Knoevenagel-phospha-Michael reaction of aldehydes, malonitrile, and phosphites in aqueous media |
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| Authors: | Sara Sobhani Zahra Pakdin Parizi |
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| Institution: | Department of Chemistry, College of Sciences, Birjand University, Birjand 414, Iran |
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| Abstract: | A new, one-pot convenient method for the synthesis of a variety of β-phosphonomalonates by a tandem Knoevenagel-phospha-Michael reaction of phosphite esters with aryl/heteroaryl/alkyl aldehydes and malonitrile in an aqueous micellar solution of sodium stearate is described. This method offers several advantages, such as using a cheap and environmentally benign reaction media, low loadings of sodium stearate as catalyst and offers good yields. |
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| Keywords: | Micelle β-Phosphonomalonates Sodium stearate Water Aldehydes Phosphites |
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