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Efficient synthesis of amino-protected calix[4]arenes selectively functionalized with iron chelator ICL670 designed as platform for iron recognition |
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| Authors: | Pascal Rouge,Mathieu Becuwe,Alexandra Dassonville-Klimpt,Sophie Da Nascimento,Jean-Franç ois Raimbert,Dominique Cailleu,Emmanuel Baudrin,Pascal Sonnet |
| Affiliation: | a UMR-CNRS 6219, Laboratoire des Glucides, Faculté de Pharmacie, Université de Picardie Jules Verne, 1 rue des Louvels, 80039 Amiens Cedex, France b Laboratoire de Réactivité et Chimie des Solides, UMR CNRS 6007, Université de Picardie Jules Verne, 33 Rue Saint Leu, 80039 Amiens Cedex, France c Plate-forme analytique, Université de Picardie Jules Verne, 80039 Amiens Cedex, France d Institut de Chimie de Picardie, FR3085 CNRS, Université de Picardie Jules Verne, 33 Rue Saint Leu, 80039 Amiens Cedex, France |
| Abstract: | The development of selective electrochemical iron sensor is still a challenging task. One promising possibility is to use organically functionalized inorganic particles, for instance silica, as sensitive element. Herein, we report on the design and synthesis of calix[4]arene-based platforms modified with ICL670 iron chelator and alkylamino chain(s). These new molecular edifices could be easily grafted on silica particles. The strategy relies on selective calix[4]arenes functionalizations by alkylamino chains at the lower rim, in partial-cone or 1,3-alternate conformations. The different synthesis routes are presented and discussed. |
| Keywords: | Calix[4]arene Lower-rim functionalization ICL670 Iron sensor |
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