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Halogen-deuterium exchange reaction mediated by tributyltin hydride using THF-d8 as the deuterium source |
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| Authors: | Tomonobu Mutsumi Hiroki IwataKazuo Maruhashi Yasunari MonguchiHironao Sajiki |
| Affiliation: | a Chemical Technology Laboratory, Taiho Pharmaceutical Co., Ltd., 200-22 Motohara, Kamikawa-machi, Kodama-gun, Saitama 367-0241, Japan b Laboratory of Organic Chemistry, Gifu Pharmaceutical University, 1-25-4 Daigaku-nishi, Gifu 501-1196, Japan |
| Abstract: | A regioselective deuteration method for a wide variety of aromatic compounds using the halogen-deuterium exchange reaction initiated by Bu3SnH using THF-d8 as the deuterium source was developed. |
| Keywords: | Halogen-deuterium exchange Deuteration THF-d8 Deuterated solvent Tributyltin hydride |
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