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Facile calculation of specific rate constants and activation energies of F-fluorination reaction using combined processes of coat-capture-elution and microfluidics |
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| Authors: | Bo Yeun Yang Jae Min Jeong Yun-Sang LeeDong Soo Lee June-Key Chung Myung Chul Lee |
| Institution: | a Department of Nuclear Medicine, Institute of Radiation Medicine, Seoul National University College of Medicine, 101 Daehangno, Jongno-gu, Seoul 110-744, South Korea b Department of Radiation Applied Life Science, Seoul National University College of Medicine, Seoul 110-744, South Korea c Cancer Research Institute, Seoul National University College of Medicine, Seoul 110-744, South Korea d Department of Molecular Medicine and Biopharmaceutical Sciences, WCU Graduate School of Convergence Science and Technology, Seoul National University, Seoul 151-742, South Korea |
| Abstract: | Calculation of a specific rate constant (k) and activation energy (Ea) of 18F-labeling reaction is important to obtain objective data. However, it has never been tried, because short time heating required for the calculation of the parameters was difficult. In the present study, we could calculate the parameters using combination of coat-capture-elution method (Aerts et al.) and microfluidic processes. The Ea values obtained for Ts-naphthol in acetone, MeCN and t-BuOH were 5.83, 8.98, and 13.54 kcal/mol, respectively, and for Ms-naphthol in the same solvents were 5.81, 8.16, and 19.34 kcal/mol, respectively. Calculation of these parameters might be useful for setting up 18F]fluorination procedure and for developing new precursors. |
| Keywords: | Activation energy Rate constant Microfluidics CCE process 18F-labeling F-18 |
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