Synthesis of fluorinated analogues of the immunosuppressive drug FTY720 |
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| Authors: | Rebecca YY KoJohn CK Chu Pauline Chiu |
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| Institution: | Department of Chemistry and the Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong, PR China |
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| Abstract: | Four fluorinated derivatives of the immunosuppressive drug FTY720 were synthesized by a convergent strategy, using the Sonogashira coupling as the key reaction to assemble the two major fragments. |
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| Keywords: | Immunosuppressive agent FTY720 Fluorinated drugs Sonogashira coupling |
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