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N-Alkoxymethylation of heterocyclic compounds with diethyl phosphite via cleavage of P-O bond |
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| Authors: | Zheng-Jun Quan Rong-Guo Ren Xiao-Dong Jia Yu-Xia Da Zhang Zhang Xi-Cun Wang |
| Affiliation: | a Key Laboratory of Eco-Environment-Related Polymer Materials, Ministry of Education, China b Gansu Key Laboratory of Polymer Materials, College of Chemistry and Chemical Engineering, Northwest Normal University, Anning East Road 967#, Lanzhou, Gansu 730070, China |
| Abstract: | N-Alkoxymethylation of heterocyclic compounds with diethyl phosphite via cleavage of P-O bond was investigated and a series of N3-ethoxymethylated heterocyclic compounds were synthesized. A mechanism in which diethyl phosphite acts as an efficient surrogate of ethanol was proposed and supported by several evidences. |
| Keywords: | Diethyl phosphite N3-Substituted dihydropyrimidinones N-Alkylation P-O cleavage |
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