| Biocatalytic synthesis of (R)-(-)-mandelic acid from racemic mandelonitrile by a newly isolated nitrilase-producer Alcaligenes sp. ECU0401 |
| |
| 引用本文： | Yu Cai He,Jian He Xu,Yi Xu,Li Ming Ouyang,Jiang Pan Laboratory of Biocatalysis and Biopwcessing,State Key Laboratory of Bioreactor Engineering,East China University of Science and Technology,Shanghai 200237,China. Biocatalytic synthesis of (R)-(-)-mandelic acid from racemic mandelonitrile by a newly isolated nitrilase-producer Alcaligenes sp. ECU0401[J]. 中国化学快报, 2007, 18(6): 677-680. DOI: 10.1016/j.cclet.2007.04.034 |
| |
| 作者姓名： | Yu Cai He Jian He Xu Yi Xu Li Ming Ouyang Jiang Pan Laboratory of Biocatalysis and Biopwcessing State Key Laboratory of Bioreactor Engineering East China University of Science and Technology Shanghai 200237 China |
| |
| 作者单位： | Yu Cai He，Jian He Xu，Yi Xu，Li Ming Ouyang，Jiang Pan Laboratory of Biocatalysis and Biopwcessing，State Key Laboratory of Bioreactor Engineering，East China University of Science and Technology，Shanghai 200237，China |
| |
| 摘 要： | By using acetonitrile as the sole nitrogen source, a microbial strain with high nitrilase activity, named as Alcaligenes sp. ECU0401, was newly isolated from soil, which could enantioselectively transform racemic mandelonitrile into (R)-(-)-mandelic acid, with an enantiomeric excess of >99.9%.
|
Biocatalytic synthesis of (R)-(-)-mandelic acid from racemic mandelonitrile by a newly isolated nitrilase-producer Alcaligenes sp. ECU0401 |
| |
| Yu Cai He,Jian He Xu,Yi Xu,Li Ming Ouyang,Jiang Pan. Biocatalytic synthesis of (R)-(-)-mandelic acid from racemic mandelonitrile by a newly isolated nitrilase-producer Alcaligenes sp. ECU0401[J]. Chinese Chemical Letters, 2007, 18(6): 677-680. DOI: 10.1016/j.cclet.2007.04.034 |
| |
| Authors: | Yu Cai He Jian He Xu Yi Xu Li Ming Ouyang Jiang Pan |
| |
| Affiliation: | Laboratory of Biocatalysis and Bioprocessing, State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China |
| |
| Abstract: | By using acetonitrile as the sole nitrogen source, a microbial strain with high nitrilase activity, named as Alcaligenes sp. ECU0401, was newly isolated from soil, which could enantioselectively transform racemic mandelonitrile into (R)-(-)-mandelic acid, with an enantiomeric excess of >99.9%. |
| |
| Keywords: | Mandelonitrile Nitrilase (R)-(-)-Mandelic acid Screening Alcaligenes sp. ECU0401 |
| 本文献已被 CNKI 万方数据 ScienceDirect 等数据库收录！ |
