Studies in the Imidazole Series. 100. Synthesis of Derivatives of Imidazo[1,2-a]pyrimidine from 2-Aminopyrimidines, Methyl Aryl Ketones, and Halogens |
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| Authors: | P M Kochergin I A Mazur G K Rogul'chenko E V Aleksandrova B E Mandrichenko |
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| Institution: | (1) Drug Chemistry Center/, All-Russian Scientific-Research Pharmaceutical Chemistry Institute, Moscow, 119815;(2) Zaporozhe State Medical University, Zaporozhe, 330074, Ukraine |
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| Abstract: | We have synthesized imidazo1,2-a]pyrimidine derivatives by reaction of 2-aminopyrimidines with methyl aryl ketones and halogens (bromine, iodine). Using bromine leads to formation of 6-bromo- and 3,6-dibromo-substituted 2-arylimidazo1,2-a]pyrimidines. |
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| Keywords: | imidazopyrimidines aminopyrimidines halogens imidazole methyl aryl ketones cyclization |
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