2,2-二甲基-5-取代苯基-3-(1,2,4-三唑-1/4-甲基)-3-戊醇类化合物的合成、表征及生物活性

取代苯甲醛经缩合、催化氢化、环氧化和开环反应合成了9种2,2-二甲基-5-取代苯基-3-(1,2,4-三唑-1-基甲基)-3-戊醇类化合物和2种2,2-二甲基-5-取代苯基-3-(1,2,4-三唑-4-基甲基)-3-戊醇类新化合物. 并对1,2,4-三唑-1-基衍生物和1,2,4-三唑-4-基衍生物的选择性合成进行了研究; 新化合物结构经质谱, ¹H NMR, 元素分析等确证, 并用单晶X射线衍射测定了化合物1a的晶体结构. 生物活性测试结果表明, 部分化合物具有强杀菌活性.

Synthesis, Structure and Biological Activity of 2,2-Dimethyl- 5-(substituted phenyl)-3-(1,2,4-triazol-1/4-ylmethyl)pentan-3-ol

Nine novel 2,2-dimethyl-5-(substituted phenyl)-3-(1,2,4-triazol-1-ylmethyl)pentan-3-ols and two novel 2,2-dimethyl-5-(substitutedphenyl)-3-(1,2,4-triazol-4-ylmethyl)pentan-3-ols were synthesized by condensa-tion, hydrogenation, epoxidation and ring-opening reactions from substituted benzaldehydes. 1,2,4-Triazol-1-yl and 1,2,4-triazol-4-yl derivatives could be selectively synthesized under certain condi-tions. Their structures were clearly established by MS, ¹H NMR spectra and elemental analy-sis. The crystal structure of compound 1a had been determined by X-ray diffraction analysis. The preliminary bioassays indicated that some compounds showed fungicidal activities.