| 2－氯／2－甲磺酰基－5－（2－苯基－4－喹啉基）－1，3，4－噁二唑化合物的合成及其亲核取代的研究 |
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| 引用本文： | 张自义,冯小明,杨丰科,管作武. 2－氯／2－甲磺酰基－5－（2－苯基－4－喹啉基）－1，3，4－噁二唑化合物的合成及其亲核取代的研究[J]. 高等学校化学学报, 1994, 0(12) |
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| 作者姓名： | 张自义 冯小明 杨丰科 管作武 |
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| 作者单位： | 兰州大学化学系，北京医科大学药学系，西南师范大学，青岛化工学院 |
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| 摘 要： | 借处理２－羟基－５－（２－苯基－４－喹啉基）－１，３，二唑同ＰＣｌ＿５／ＰＯＣｌ＿３之间的反应合成了２－氯－５－（２－苯基－４－喹啉基）－１，３，４－二唑（３）和通过２－基－５－（２－苯基－４－喹啉基）－１，３，４－二唑的甲基化，然后氧化制得２－甲磺酰基－５－（２－苯基－４－喹啉基）－１，３，４－二唑（６）．并分别研究了３和６同胺、叠氮及肼的反应，得到２，５－二取代的二唑新衍生物．初步观察了部分化合物的抗菌活性．
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| 关 键 词： | 1，3，4－ 二唑，合成，亲核取代 |
Synthesis of 2-Chloro/2-methylsulphonyl-5-(2-phenyl-4-quinolyl)-1, 3, 4-oxadiazole Compounds and Their Nucleophilic Displacement |
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| ZHANG Zi-Yi, FENG Xiao-Ming,YANG Feng-Ke. Synthesis of 2-Chloro/2-methylsulphonyl-5-(2-phenyl-4-quinolyl)-1, 3, 4-oxadiazole Compounds and Their Nucleophilic Displacement[J]. Chemical Research In Chinese Universities, 1994, 0(12) |
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| Authors: | ZHANG Zi-Yi FENG Xiao-Ming YANG Feng-Ke |
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| Abstract: | Substituted compounds of 2-chloro-5-(2-phenyl-4-quinolyl)-1, 3, 4-oxadiazole 3 and 2-methylsulphonyl-5-(2-phenyl-4-quinolyl)-1, 3, 4-oxadiazole 6 have been synthesized and the reactions of 3 and 6 with a variety of nucleophilic reagent, such as, amine, azide and hydrazine were also investigated. 3 has been prepared by the treatment of 2-hydroxy-5-(2-phenyl-4-quinolyl)-1, 3, 4-oxadiazole with PCl5/POCl3. Whereas the 2-methylsulphonyl derivatives 6 has been obtained from 2-mercapto-5-(2-phenyl-4-quinolyl)-1, 3,4-oxadiazole through methylation and subsequent oxidation with KMnO4. |
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| Keywords: | Oxadiazole Synthesis Nucleophilic substitution |
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