Reductive Acylamination of Pyridine N-Oxide with Aminopyridines and Their N-p-Tolylsulfonyl Derivatives |
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Authors: | M. A. Solekhova Yu. V. Kurbatov |
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Affiliation: | (1) Alisher Navoi Samarkand State University, Universitetskii bul’var 15, Samarkand, 703004, Kazakhstan |
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Abstract: | Pyridine N-oxide reacts with 2- and 3-aminopyridines and their N-p-tolylsulfonyl derivatives in alkaline medium in the presence of p-toluenesulfonyl chloride to give N-p-tolylsulfonyl-2,2′- and 2,3′-dipyridylamines, respectively, as a result of reductive acylamination. In the reactions with 4-aminopyridine and 4-p-tolylsulfonyl-aminopyridine, their N-p-tolylsulfonyl- and N,N-bis(p-tolylsulfonyl) derivatives are formed, while reductive acylamination does not occur.__________Translated from Zhurnal Organicheskoi Khimii, Vol. 41, No. 1, 2005, pp. 128–130.Original Russian Text Copyright © 2005 by Solekhova, Kurbatov. |
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