Monitoring of Anti Cancer Drug Letrozole by Fast Fourier Transform Continuous Cyclic Voltammetry at Gold Microelectrode |
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Authors: | Norouzi Parviz Ganjali Mohammad Reza Qomi Mahnaz Nemati Kharat Ali Zamani Hassan Ali |
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Institution: | 1. Center of Excellence in Electrochemistry, Department of Chemistry, University of Tehran, Tehran, Iran;2. Endocrinology & Metabolism Research Center, Tehran University of Medical Science, Tehran, Iran;3. Department of Medicinal Chemistry, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran;4. School of Chemistry, University College of Science, University of Tehran, Tehran, Iran;5. Department of Applied Chemistry, Quchan Branch, Islamic Azad University, Quchan, Iran |
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Abstract: | A continuous cyclic voltammetric study of letrozole at gold microelectrode was carried out. The drug in phosphate buffer (pH 2.0) is adsorbed at ?200 mV, giving rise to change in the current of well‐defined oxidation peak of gold in the flow injection system. The proposed detection method has some of advantages, the greatest of which are as follows: first, it is no more necessary to remove oxygen from the analyte solution and second, this is a very fast and appropriate technique for determination of the drug compound in a wide variety of chromatographic analysis methods. Signal‐to‐noise ratio has significantly increased by application of discrete Fast Fourier Transform (FFT) method, background subtraction and two‐dimensional integration of the electrode response over a selected potential range and time window. Also in this work some parameters such as sweep rate, eluent pH, and accumulation time and potential were optimized. The linear concentration range was of 1.0×10?7?1.0×10?10 mol/L (r=0.9975) with a limit of detection and quantitation 0.08 nmol/L and 0.15 nmol/L, respectively. The method has the requisite accuracy, sensitivity, precision and selectivity to assay letrozol in tablets. The influences of pH of eluent, accumulation potential, sweep rate, and accumulation time on the determination of the letrozol were considered. |
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Keywords: | letrozole cyclic voltammetry fast Fourier transform |
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