Metal and Substituent Influence on the Cytostatic Activity of Cationic Bis-cyclometallated Iridium and Rhodium Complexes with Substituted 1,10-Phenanthrolines as Ancillary Ligands |
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| Authors: | Marion Graf Daniel Siegmund Yvonne Gothe Nils Metzler-Nolte Karlheinz Sünkel |
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| Institution: | 1. Department of Chemistry, Ludwig-Maximilians University Munich, Butenandtstr. 9, 81377 Munich, Germany;2. Inorganic Chemistry I Bioinorganic Chemistry, Faculty of Chemistry and Biochemistry, Ruhr University Bochum, 44801 Bochum, Germany |
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| Abstract: | Synthesis and characterization of the new cyclometalated complex salts Rh(ptpy)2(5.6-dimethyl-1,10-phenanthroline)]PF6 ( 1a ) Rh(ptpy)2(2.9-dimethyl-4.7-diphenyl-1,10- phenanthroline)]PF6 ( 2a ), Rh(ptpy)2(5-amino-1,10-phenanthroline)] PF6 ( 3a ), and M(ptpy)2 (pyrazino-2.3-f]-1,10-phenanthroline)]PF6 (M = Rh, 4a ; M = Ir, 4b ), (ptpy = 2-(p-tolyl)pyridinato) are described. The molecular structures of compounds 1b and 4a in the solid state were determined by single-crystal X-ray diffraction. All these compounds and their already known Iridium counterparts 1b – 3b display significant cytotoxicity against human cancer cell lines MCF-7 (human breast adenocarcinoma) and HT-29 (colon adenocarcinoma) with IC50 values in the low micromolar range. |
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| Keywords: | Cyclometallate complexes Rhodium Iridium Phenanthrolines Cytostatic activity |
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