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A Long-term and Stable Surface Modification Method for Lanthanide Doped Upconversion Nanoparticles by Oxidized Alginate |
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| Authors: | Cong Cao Chang Hong Yu Li Guangshen Li Guohua Jiang |
| Institution: | 1. College of Materials Science and Engineering, Zhejiang Sci-Tech University, 310018 Hangzhou, P. R. China;2. College of Materials Science and Engineering, Zhejiang Sci-Tech University, 310018 Hangzhou, P. R. China
Institute of Smart Biomedical Materials and Zhejiang-Mauritius Joint Research Center for Biomaterials and Tissue Engineering, Zhejiang Sci-Tech University, 310018 Hangzhou, P. R. China |
| Abstract: | Lanthanide doped upconversion luminescent nanoparticles (UCNPs) have drawn widely attention in biomedical research. The generally synthesized oleate capped UCNPs have no aqueous dispersibility so that surface modification is required to be water dispersible. Herein, we developed an easy-going but effective approach to prepare hydrophilic UCNPs based on oxidized alginate molecule (OAlg). After surface modification treatment, the OAlg modified UCNPs (UCNPs-OAlg) shows excellent dispersibility and longer stability in aqueous solution even after 180 days. After incubation with UCNPs-OAlg, the upconversion luminescent images of living Hela cells were clearly obtained. It indicated that oxidized alginate modified UCNPs can be candidate for excellent imaging probes in future. |
| Keywords: | Upconversion Oxidized alginate Surface modification Bioimaging |