Synthesis and stereochemistry of novel [1,2,4]oxadiazolo[4,5-a][1,5]benzodiazepine derivatives |
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Authors: | Alba Chimirri,Silvana Grasso,Rosaria Ottan ,Giovanni Romeo,Maria Zappal |
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Affiliation: | Alba Chimirri,Silvana Grasso,Rosaria Ottanà,Giovanni Romeo,Maria Zappalà |
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Abstract: | An one-pot synthetic approach to the novel 3a,4,5,6-tetrahydro[1,2,4]oxadiazolo[4,5-a][1,5]benzodiazepine system, by 1,3-dipolar cycloaddition of benzonitriloxides to 1,5-benzodiazepine derivatives, is described. The structure and stereochemistry of the obtained adducts have been assigned by means of spectroscopic measurements. |
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