Nitrogen bridgehead compounds. Part 77. Addition reaction of 9-methylene-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-ones |
| |
Authors: | G bor T th,Frank Janke,Istv n Hermecz,Istv n Bitter |
| |
Affiliation: | Gábor Tóth,Frank Janke,István Hermecz,István Bitter |
| |
Abstract: | Addition of bromine or thioacetic acid onto 6-methyl-9-methylenetetrahydro-4H-pyrido[1,2-a]pyrimidin-4-ones is stereoselective and gives the cis 6-Me,9-CH substituted products. Addition is also stereoselective in respect to the C(9) and C(10) centers, and gives as the primary product the erythro diastereomer, which may then undergo epimerization to the threo isomer. Relative configuration and predominant conformation of the products were determined by 1D and 2D nmr methods. |
| |
Keywords: | |
|
|