Synthesis of Quinoline-8-selenol, Its Complex Compounds with Metals and Their Cytotoxic Activity |
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Authors: | J Ashaks Yu Bankovsky D Zaruma I Shestakova I Domracheva A Nesterova E Lukevics |
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Institution: | (1) Institute of Inorganic Chemistry, Riga Technical University, Salaspils, LV-2169, Latvia;(2) Latvian Institute of Organic Synthesis, Riga, LV-1006, Latvia |
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Abstract: | We have developed a novel method for synthesis of quinoline-8-selenol using selenourea instead of the previously used potassium selenocyanate. We have synthesized a series of metal quinoline-8-selenolates. We have studied the cytotoxic activity of the synthesized compounds against HT-1080, MG-22A, B16, Neuro 2A tumor cells. Mercury quinoline-8-selenolate is distinguished by high cytotoxicity for the three cell lines; the cadmium complex is most effective against B16 melanoma cells. |
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Keywords: | quinoline-8-selenol metal quinoline-8-selenolates cytotoxicity |
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