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Stepwise synthesis of RNA conjugates carrying peptide sequences for RNA interference studies |
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| Authors: | Anna Avi?ó Sandra M Ocampo Clara Caminal José Carlos Perales Ramon Eritja |
| Institution: | 1. Institute for Research in Biomedicine (IRB Barcelona), Edifici Helix, Baldiri Reixac 15, 08028, Barcelona, Spain 2. Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), Edifici Helix, Baldiri Reixac 15, 08028, Barcelona, Spain 3. Networking Centre on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Edifici Helix, Baldiri Reixac 15, 08028, Barcelona, Spain 4. Department of Ciencies Fisiológiques, School of Medicine, University of Barcelona, Campus Bellvitge, C/Feixa Llarga, L’Hospitalet de Llobregat, 08907, Barcelona, Spain |
| Abstract: | Oligoribonucleotide conjugates carrying nuclear localization peptide sequences at the 3′-end were prepared stepwise on a single support. The siRNA duplex carrying the nuclear localization peptide sequence at the 3′-end of the passenger strand has similar inhibitory properties as those of unmodified or cholesterol-modified RNA duplexes. |
| Keywords: | siRNA Oligonucleotide-peptide conjugates RNA interference Tumor necrosis factor Oligonucleotide synthesis Soild-phase |
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