Fe(II)/alpha-ketoglutarate hydroxylases involved in nucleobase, nucleoside, nucleotide, and chromatin metabolism |
| |
Authors: | Simmons Jana M Müller Tina A Hausinger Robert P |
| |
Institution: | Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824-1319, USA. |
| |
Abstract: | Fe(II)/alpha-ketoglutarate-dependent hydroxylases uniformly possess a double-stranded beta-helix fold with two conserved histidines and one carboxylate coordinating their mononuclear ferrous ions. Oxidative decomposition of the alpha-keto acid is proposed to generate a ferryl-oxo intermediate capable of hydroxylating unactivated carbon atoms in a myriad of substrates. This Perspective focuses on a subgroup of these enzymes that are involved in pyrimidine salvage, purine decomposition, nucleoside and nucleotide hydroxylation, DNA/RNA repair, and chromatin modification. The varied reaction schemes are presented, and selected structural and kinetic information is summarized. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|