Enantioselective cyclization/hydrosilylation of 1,6-enynes catalyzed by a cationic rhodium bis(phosphine) complex |
| |
| Authors: | Chakrapani Harinath Liu Cong Widenhoefer Ross A |
| |
| Institution: | P. M. Gross Chemical Laboratory, Duke University, Durham, North Carolina 27708-0346, USA. |
| |
| Abstract: | reaction: see text] Reaction of 4,4-dicarbomethoxy-1-octene-6-yne (1) with triethylsilane and a catalytic 1:1 mixture of Rh(COD)(2)](+) SbF(6)(-) and (R)-BIPHEMP (5 mol %) at 70 degrees C for 90 min gave (Z)-1,1-dicarbomethoxy-3-(1-triethylsilyl)ethylidene-4-methylcyclopentane (2) in 81% isolated yield with 98% de and 92% ee. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
