Zinc and copper complexes of prodigiosin: implications for copper-mediated double-strand DNA cleavage |
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| Authors: | Park Gyungse Tomlinson John T Melvin Matt S Wright Marcus W Day Cynthia S Manderville Richard A |
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| Affiliation: | Department of Chemistry, Wake Forest University, Winston-Salem, North Carolina 27109-7486, USA. |
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| Abstract: | [reaction: see text] Zinc(II) and copper(II) complexes of prodigiosin (1) have been characterized. All N-atoms of 1 bind Cu(II) to generate 5: the complex exhibits regiospecific oxidation of the C-pyrrole. In contrast, coordination by Zn(II) to 1 produces Zn(1)(2) (8), a 4-coordinate tetrahedral complex. The influence of these binding geometries on Cu-mediated double-strand (ds) DNA cleavage by 1 is discussed. |
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