Zinc and copper complexes of prodigiosin: implications for copper-mediated double-strand DNA cleavage |
| |
| Authors: | Park Gyungse Tomlinson John T Melvin Matt S Wright Marcus W Day Cynthia S Manderville Richard A |
| |
| Institution: | Department of Chemistry, Wake Forest University, Winston-Salem, North Carolina 27109-7486, USA. |
| |
| Abstract: | reaction: see text] Zinc(II) and copper(II) complexes of prodigiosin (1) have been characterized. All N-atoms of 1 bind Cu(II) to generate 5: the complex exhibits regiospecific oxidation of the C-pyrrole. In contrast, coordination by Zn(II) to 1 produces Zn(1)(2) (8), a 4-coordinate tetrahedral complex. The influence of these binding geometries on Cu-mediated double-strand (ds) DNA cleavage by 1 is discussed. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
