Solid-phase synthesis of tetrasubstituted pyrrolo[2,3-d]pyrimidines |
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| Authors: | Lee Ji Hoon Lim Hyun-Suk |
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| Affiliation: | Department of Biochemistry and Molecular Biology, and Indiana University Simon Cancer Centre, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA. |
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| Abstract: | A facile solid phase synthesis of 2,4,6,7-tetrasubstituted pyrrolo[2,3-d]pyrimidines is described. The synthesis involves a highly efficient five-step route starting from resin-bound dimeric peptoids. To demonstrate the versatility of our method, a representative library of 108 tetrasubstituted pyrrolo[2,3-d]pyrimidines of high quality was synthesized. |
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