Physico-chemical characterisation of a new polymorph of caffeine |
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Authors: | Emma Dichi Bernard Legendre Mehrez Sghaier |
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Affiliation: | 1. Matériaux et Santé, EA 401 Faculté de Pharmacie, Université Paris Sud, 5 rue J. B. Clément, 92296, Chatenay-Malabry, France
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Abstract: | Caffeine is a widely used drug substance. Two polymorphic forms and one hydrate of caffeine are known. Thanks to scanning transitiometry, the curves pressure versus temperature, P = f(T), of the caffeine were plotted. A (temperature, pressure) unary phase diagram was deduced. It confirms the existence of a new polymorph of caffeine at low pressure synthesized by sublimation. Its identification and its physico-chemical properties were determined using a variety of experimental methods: X-ray powder diffraction, differential scanning calorimeter, thermogravimetric analysis, thermally stimulated current and electrochemical impedance. |
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