To determine the half-life for gemcitabine hydrochloride using microcalorimetry |
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Authors: | Dai-Huo Liu Wei-Wei Zhao Zong-Xiao Li |
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Institution: | 1. Department of Chemistry and Chemical Engineering, Baoji University of Arts and Sciences, Baoji, 721013, Shaanxi, China
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Abstract: | The enthalpies of dissolution of gemcitabine hydrochloride in 0.9 % normal saline (medical) and citric acid solution were measured using a microcalorimeter at 309.65 K under atmospheric pressure. The differential enthalpy $ \left( {\Updelta_{\text{dif}} H_{\text{m}}^{{{\theta}}} } \right) $ and molar enthalpy $ \left( {\Updelta_{\text{sol}} H_{\text{m}}^{{{\theta}}} } \right) $ of dissolution were determined, respectively. The corresponding kinetic equation described the dissolution were elucidated to be da/dt = 10?3.84(1 ? a)0.92 and da/dt = 10?3.80(1 ? a)1.21. Besides, the half-life, $ \Updelta_{\text{sol}} H_{\text{m}}^{{{\theta}}} ,\Updelta_{\text{sol}} G_{\text{m}}^{{{\theta}}} $ and $ \Updelta_{\text{sol}} S_{\text{m}}^{{{\theta}}} $ of the dissolution were also obtained. Obviously, it will provide a simple and reliable method for the clinical application of gemcitabine hydrochloride. |
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