Organocatalytic enantioselective synthesis of β-blockers: (S)-propranolol and (S)-naftopidil |
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| Authors: | Sharad P. Panchgalle Rohitkumar G. Gore Subhash P. Chavan Uttam R. Kalkote |
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| Affiliation: | aDivision of Organic Chemistry, National Chemical Laboratory, Dr. Homi Bhabha Road, Pune 411 008, India |
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| Abstract: | An efficient enantioselective synthesis of β-adrenergic blockers (S)-propranolol and (S)-naftopidil with >98% ee using an l-proline-catalyzed α-aminoxylation of an aldehyde as a key step is described. |
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