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Helical folding in heterogeneous foldamers without inter-residual backbone hydrogen-bonding
Authors:Gowri Priya  Amol S Kotmale  Rupesh L Gawade  Deepti Mishra  Sourav Pal  Vedavadi G Puranik  Pattuparambil R Rajamohanan  Gangadhar J Sanjayan
Affiliation:Division of Organic Synthesis, National Chemical Laboratory, Dr Homi Bhabha Road, Pune 411 008, India. gj.sanjayan@ncl.res.in.
Abstract:This communication describes a set of hybrid foldamers that do not feature inter-residual, but intra-residual backbone hydrogen-bonding, yet adopt a preferentially folded conformation displaying right-handed helical architecture. Conformational ordering is apparently due to the combined conformational restrictions imposed by the conformationally restricted individual amino acid residues with which the oligomers are made of.
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