Oxidative coupling of indoles with ethyl 2-(disubstituted amino)acetates: an approach to achieve indolylglycine derivatives |
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| Authors: | Zhanwei Xu Xiaoqiang Yu Xiujuan Feng Ming Bao |
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| Affiliation: | State Key Laboratory of Fine Chemicals, Dalian University of Technology , Dalian 116023, China. |
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| Abstract: | An efficient method for the synthesis of indolylglycine derivatives is described. The oxidative coupling reactions of ethyl 2-(disubstituted amino)acetates with indoles proceeded smoothly in the presence of meta-chloroperoxybenzoic acid (mCPBA) under ambient conditions to produce indolylglycine derivatives in satisfactory to excellent yields. |
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